Tuberous sclerosis complex (TSC) is a rare genetic disease caused by heterozygous dominant mutations in the TSC1 or TSC2 genes that affects 1/6000 newborns (Curatalo et al., 2002; de Vries & Howe, 2007). TSC has a variety of clinical manifestations ranging from hypomelanotic macules to neurological conditions such as epilepsy (Neuman & Henske, 2011; de Vries & Howe, 2007). In cases where the TSC mutations are inherited from parent to offspring (familial TSC)- the child can still exhibit more severe symptoms despite having the same TSC mutation as the parent, a phenomenon known as intrafamilial phenotypic variability (IPV) (Curatalo et al, 2002). We hypothesize that the variants in genes of the mTOR signaling pathway (genetic modifiers) may enhance or suppress mTOR pathway activity, resulting in IPV. Patient derived primary fibroblasts cell lines from two families exhibiting IPV were studied as well as an unrelated control cell line. We identified variants in IRS1, FZD5, and PIK32CG genes from children with severe phenotype in one family and variants in PIK3R3, TNFRSF19, and EIF4G1 in a severe child in another pathway. We explored the functional impact of these genes on mTOR pathway activity.

Suicide is a significant public health problem, with incidence rates and lethality continuing to increase yearly. Given the large human and financial cost of suicide worldwide alongside the lack of progress in suicide prediction, more research is needed to inform suicide prevention and intervention efforts. This study approaches suicide from the lens of suicide note-leaving behavior, which can provide important information on predictors of suicide. Specifically, this study adds to the existing literature on note-leaving by examining history of suicidality, mental health problems, and their interaction in predicting suicide note-leaving, in addition to demographic predictors of note-leaving examined in previous research using data from the National Violent Death Reporting System (NVDRS, n = 98,515). We fit a logistic regression model predicting leaving a suicide note or not, the results of which indicated that those with mental health problems or a history of suicidality were more likely to leave a suicide note than those without such histories, and those with both mental health problems and a history of suicidality were most likely to leave a suicide note. These findings reinforce the need to tailor suicide prevention efforts toward identifying and targeting higher risk populations.

As the use of social media becomes more prevalent, especially in adolescents and young adults, there is a growing need to understand how social media use affects psychological well-being in the emerging adult population. Prior research has found that exposure to nature reduces stress and increases attention in comparison to urban environments, but nature has not been studied as a way to reduce the potentially negative effects of social media. The current study aimed to determine if viewing social media or nature for a brief time affected psychological well-being, social comparisons, future self-identification, and awe, and to test whether viewing nature scenes could buffer the effects of viewing social media. Data was collected from 275 participants using a survey on Amazon Mechanical Turk. Results showed that emerging adults exposed to nature scenes had significantly less negative affect compared to those exposed to their social media feeds. Exploratory analyses showed that those who spent more time outside tended to experience decreased negative affect when they viewed both social media and nature photos, but those who spent more time outside experienced increased negative affect when only viewing social media. Those who used social media more often generally experienced lower negative affect. Findings show that relations between humans, social media, and nature, are complex, and further research into these relations and their underlying causes may be beneficial.

This scoping review provides a synthesis of research which maps the literature on the topic of COVID-19 related impact on Undergraduate Student Mental Health and Baccalaureate Success. The purpose of this review was to identify existing literature pertaining to the psychological repercussions of COVID-19 on the undergraduate population, describe the range of successful interventions used to reduce stress and demand on the U.S. undergraduate population during a pandemic, and identify implications for future research. Due to the novelty of coronavirus and limited research on the given topic, this review provides a framework of available research by identifying types of available research, identifying how research is conducted on the topic, identifying and analyzing knowledge gaps, and clarifies key concepts in literature.

SUMMARY: A failed attempt to conduct a systematic review of disparities in racial inclusivity in stroke rehabilitation research: A call to action Group Members: Adeline Beeler & Mikayla McNally Faculty Mentor(s): Dr. Sydney Schaefer & Dr. Keith Lohse Topic Overview: Stroke is responsible for the death of an individual every four minutes in the United States. While all Americans are gravely affected by this statistic, Black Americans are at a significantly increased risk of first stroke incidence when compared to their white counterparts, majorly due to heightened prevalence of stroke risk factors. Not only does race contribute as a factor in stroke incidence, but it also has a considerable impact in the physical impairment of Black Americans following stroke occurrence. While it still remains unclear as to whether or not stroke plays a significant role in stroke rehabilitation efforts, there is a clearly demonstrated need for increased reporting or participation of Black Americans in stroke rehabilitation clinical trials to have the ability to conduct a systematic review of these racial disparities in the near future. In the analysis of 36 stroke rehabilitation-related clinical research studies, 80% of selected trials failed to report any participant racial demographics, with 77.3% of the NIH-funded trials not reporting, as well. Out of the 7 trials that did provide some sort of participant racial information, only 5 successfully provided statistically significant racial data compared to the remainder that simply categorized participants’ race as “white” or “other.” In order to fully investigate the effects of race on stroke rehabilitation, it is imperative that researchers collect and report equally distributed and diverse participant racial data when publishing clinical research. Potential methods of improvement for researchers to include more racially diverse subject populations include more comprehensive and in-depth advertising and recruitment strategies for their studies. Research Methods: In order to produce accurate analyses of the current state of the relationship between race and stroke rehabilitation efforts, 36 stroke rehabilitation clinical research trials from various locations across the United States were identified using the Centralized Open-Access Rehabilitation Database for Stroke (SCOAR). These trials were evaluated in order to extract relevant data, such as number of trial participants, average age of participants, if the research trial was funded by the National Institute of Health (NIH) or not, and any reported participant racial demographic details. Trends across these categories were compared between all trials to determine if any disparities existed in providing data sufficient to support the relationship between varying racial populations and stroke rehabilitation efforts. Future Project Efforts: Future efforts will include the completion of submitting a Point of View/Directions for Research article for publication to offer an opportunity for clinical and basic researchers to examine the discrepancies surrounding racial inclusivity in stroke rehabilitation clinical research. The aim is to improve the ability of clinicians to interpret the literature, translate research studies into practices, and better direct future experiments. Further identification of stroke rehabilitation clinical research trials will be necessary, as well as modifications to current written work content.

Host plant choice by herbivorous insects can be driven by a variety of factors including plant nutrient composition and mechanical properties. In this study, I investigated the role of plant protein and carbohydrate composition, water content, and leaf thickness on plant preference for the Australian Plague Locust (Chortoicetes terminifera). For this, I used four economically important cereal crop species: barley Hordeum vulgare, wheat Triticum aestivum L., rye Secale cereale, and corn Zea mays. Using a full factorial design, I gave the choice to the locusts between two plant species then I measured 1) visual preference by pairing, 2) surface area consumed, and 3) dry mass consumed. For each leaf, I measured protein content, carbohydrate content, foliar wet mass, and Specific Leaf Area (SLA, a measure of plant thickness). I found plant nutrient content was not a good predictor of host plant choice in the short term, however, leaf thickness had a significant relationship with dry amount of leaf consumed and defoliation. Overall locusts preferred plants that were thinner. I discuss these results in light of our current knowledge of the nutritional ecology of this important cereal crop pest.

My Honors thesis examines how promotoras, otherwise known as community health workers, can be beneficial to a community and any challenges that might be faced when implementing this program. My honors thesis will provide the history of promotoras, context on various health issues Latinx face historically and with the context of the COVID-19 pandemic, and finally address the findings of my interviews and shadowing of promotoras.