Predicting Glioblastoma Growth Using a Poisson Process
Description
In this research we consider stochastic models of Glioblastoma Multiforme brain tumors. We first look at a model by K. Swanson et al., which describes the dynamics as random diffusion plus deterministic logistic growth. We introduce a stochastic component in the logistic growth in the form of a random growth rate defined by a Poisson process. We show that this stochastic logistic growth model leads to a more accurate evaluation of the tumor growth compared its deterministic counterpart. We also discuss future plans to incorporate individual patient geometry, extend the model to three dimensions and to incorporate effects of different treatments into our model, in collaboration with a local hospital.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2013-12
Agent
- Author (aut): Manning, Michael Clare
- Thesis director: Kostelich, Eric
- Committee member: Kuang, Yang
- Committee member: Gardner, Carl
- Contributor (ctb): Barrett, The Honors College
- Contributor (ctb): School of Mathematical and Statistical Sciences
- Contributor (ctb): School of Letters and Sciences
- Contributor (ctb): School of Human Evolution and Social Change