The United States building sector was the most significant carbon emission contributor (over 40%). The United States government is trying to decrease carbon emissions by enacting policies, but emissions increased by approximately 7 percent in the U.S. between 1990 and 2013. To reduce emissions, investigating the factors affecting carbon emissions should be a priority. Therefore, in this dissertation, this research examine the relationship between carbon emissions and the factors affecting them from macro and micro perspectives. From a macroscopic perspective, the relationship between carbon dioxide, energy resource consumption, energy prices, GDP (gross domestic product), waste generation, and recycling waste generation in the building and waste sectors has been verified. From a microscopic perspective, the impact of non-permanent electric appliances and stationary and non-stationary occupancy has been investigated. To verify the relationships, various kinds of statistical and data mining techniques were applied, such as the Granger causality test, linear and logarithmic correlation, and regression method. The results show that natural gas and electricity prices are higher than others, as coal impacts their consumption, and electricity and coal consumption were found to cause significant carbon emissions. Also, waste generation and recycling significantly increase and decrease emissions from the waste sector, respectively. Moreover, non-permanent appliances such as desktop computers and monitors consume a lot of electricity, and significant energy saving potential has been shown. Lastly, a linear relationship exists between buildings’ electricity use and total occupancy, but no significant relationship exists between occupancy and thermal loads, such as cooling and heating loads. These findings will potentially provide policymakers with a better understanding of and insights into carbon emission manipulation in the building sector.