Urbanization is a landscape-level alteration of habitat that can lead to habitat fragmentation, degradation, and the introduction of nonnative species. Due to their life history characteristics, mammalian predators are particularly vulnerable to these effects. The categorization of many species as synanthropic, benefiting from human development, has been difficult as species have a gradient of responses to urbanization. Although coyotes, gray foxes and bobcats have all been shown to benefit from light to moderate levels of urbanization, often due to the increase in food resources, they typically require access to natural areas as escape cover. Camera traps at varying distances were used to document mesopredator response to the urban edge of Gold Canyon, Arizona from November 2015 through March 2016. Coyote, gray fox and bobcat relative abundance did not vary with distance to urban edge during this time period. Although, negative trends suggest that a larger scale study may reveal a negative relationship between distance to urban edge and mesopredator abundance for all 3 of these species. The efficacy of different baits at increasing mesopredator detections was also tested, with insignificant results. However, coyotes seemed to be more likely to interact with Carman's Raccoon Lure No. 2 than coyote urine. Understanding the responses of mesopredators to urbanization will allow us to better coexist with these vulnerable species as land continues to be developed at high rates across the globe.

Abstract: International Service Devils (ISD) is a non-profit volunteer program established and run by students at Arizona State University, Polytechnic Campus. Since 2013, International Service Devils has volunteered in Costa Rica, Guatemala, and India. This blog, written by Kali Richmond and myself, shares the experience of how we as students have established a new volunteer program in Ho Chi Minh City, Vietnam. We have described in an entertaining fashion, our entire learning process from the brainstorming and organizing, to the results of the trip itself. This includes the struggles that we had to overcome with planning and finances, as well as crediting the people and organizations who helped us along the way to overcome those obstacles. We established 2 volunteer projects as well as completed multiple community analyses for the possibility of starting a school and providing scholarships to deserving children through the Young Dreamer Network. This blog is accompanied by an approximately 15 minute video of footage and photos taken during our time in Vietnam. The video shows both the volunteer aspect as well as some of the cultural experiences that we experienced. The purpose of this documentation is to encourage international service learning as a source of experience and education for University students, and to show plausibility of setting goals similar to ours and being able to achieve them. We hope that our writing can help students get an idea of what it takes to be a leader in international service learning programs, and that our experience can help prove the worth of volunteering abroad. We want to inspire fellow students to travel with the mission to learn from wherever they go and be able to give back to those communities, as this has provided us with immense personal growth and new perspectives on education and culture.

The stress levels of the average person in today's society are extremely high and this can have a massive effect on health, especially on the cardiovascular system. The two most common types of stress, acute and chronic, effect the cardiovascular system differently. Acute stress comes from a short term source of perceived danger, such as giving a presentation in front of a crowd, or being chased by a wild animal. Chronic stress is the dull anxiety that hangs around consistently and comes from long-term sources of stress, such as a negative work environment or feeling trapped in a poor relationship. A review of the available research literature shows that while acute stress can have positive or negative effects on the body, chronic stress is consistently damaging to cardiovascular health. The adrenaline rush associated with acute stress can increase focus and improve performance through a variety of physiological reactions such as increased heart rate and changes in blood flow to support the most vital organs. Chronic stress sufferers have an increased chance of heart disease, heart attack, and a variety of other problems due to the negative consequences of chronic stress such as high blood pressure. The high negative impact chronic stress and excessive amounts of acute stress can have leads to the conclusion that stress needs to be regulated and limited. Prioritizing health by getting sufficient sleep, taking time to exercise, and practicing relaxation techniques such as meditation can all help to minimize stress levels and the dangerous potential consequences of excess stress.

Background: Esophageal adenocarcinoma (EAC) is one of the only malignancies whose incidence is rising in the United States. Current multidrug treatment for EAC has considerable toxic side effects that necessitate the development of less toxic, more specific target drugs. Recent large scale genomic analysis reveals that TP53 is the most frequently inactivated gene in EAC. One of the primary functions of TP53 and its gene product, the tumor suppressor p53, is in regulation of DNA repair in response to DNA damage. Inactivation of TP53 results in loss of the G1/S cell cycle checkpoint, and dependence on the G2/M checkpoint for DNA repair. Activity of cyclin-dependent kinase 1 (CDK1) is necessary for cells to exit the G2/M checkpoint and enter mitosis. Phosphorylation of CDK1 by the wee1 kinase inhibits CDK1 in response to DNA damage, allowing cells to maintain G2 arrest and repair the damaged DNA. Active in normal cells, wee1 kinase is critical in cancer cells to promote DNA repair and cell survival in response to DNA damage, particularly from commonly used DNA damaging therapies. AZD1775 is a small molecule inhibitor of wee1 kinase, currently under investigation in clinical trials. AZD1775 differentially targets cancer cells by blocking wee1 mediated inhibition of CDK1 and consequently preventing G2/M arrest in response to DNA damage. Combination of AZD1775 with DNA damaging agents is thought to push cancer cells with damaged DNA through to mitosis and initiate apoptosis instead of G2/M arrest and DNA repair. Based upon the incidence of TP53 mutation in EAC, we hypothesize that treatment with a DNA damaging agent in combination with AZD1775 will be as effective at eliciting DNA damage and cell death as the more toxic current standard of care, which is comprised of treatment with cisplatin, docetaxel, and radiation. Methods: p53 mutant EAC cell lines were dosed with cisplatin, AZD1775, and the combination of cisplatin and AZD1775, and then assayed for viability. Nude mice were implanted with p53 mutant patient derived xenograft esophageal adenocarcinoma tumors and randomized for treatment with AZD1775 alone, cisplatin and AZD1775, radiation and AZD1775, cisplatin, docetaxel, and radiation or vehicle (control). Tumor volume was measured over the five week treatment course. Results: In vitro and in vivo assays reveal a potent synergistic effect between AZD1775 and DNA damaging agents that is as efficacious as the standard of care therapy. The difference in AZD1775 sensitivity among TP53 mutant EAC cell lines indicates that TP53 alone may not be an adequate biomarker to assess for AZD1775- mediated toxicity.

This thesis examines the problems that occur when the politics and practices of social services, specifically maternal and prenatal care, are guided by a distorted understanding of immigration. It compares the politics and practice of this care across two international borders: the U.S.-Mexico and that within Hispaniola. In an ideal world, care would be extended to all individuals regardless of citizenship. However, since every welfare state has its limits at the national border, citizenship matters to both federal governments and medical professionals. Government-provided resources play an integral role in the current immigration debate, as these programs are a collective investment in which all individuals contribute in order to sustain it. The United States developed the welfare state in order to provide necessary resources to those who could not afford it. Its creators did not view these services as a handout, rather as a support for the future workforce of the country. However, health care was and still is not provided on this model of economic and social citizenship. Current U.S. healthcare policy dictates that no one can be turned away in an emergency situation because someone cannot pay their medical bill, including undocumented immigrants. But for immigrant mothers carrying children across the border, maternal and prenatal care does not qualify as an emergency and the federal government aid typically does not extend to them them as citizens. When care is extended to undocumented immigrants in the United States at all, it typically is provided to the child through Medicaid, who is by dint of the Fourteenth Amendment considered a citizen after birth. The relation between the Dominican Republic and Haiti offers a more complex situation, as the idea of birthright citizenship has recently been revoked. Following the Haitian Earthquake in 2010, the only healthcare to which many Haitians had access was across the Hispaniola border. Haitian women who give birth to children in the Dominican Republic are often not evaluated by a doctor until they are entering the delivery process, and even then health-care is complicated by or denied because of racial prejudice and unclear legal situation. In September of 2013, the Constitutional Court of the Dominican Republic issues a new ruling which declared that any immigrant born between 1929 and 2010 without documentation of their own or of their ancestors does not have citizenship, rendering many Haitians born in the Dominican Republic essentially stateless. To be born to a non-citizen mother typically means the child will likely be born with little or no prenatal care, and the mother will receive poor or inadequate care. Prenatal care is one of the most inexpensive elements of a care-model that carries huge returns relative to its costs. All governments would benefit from improved access to maternal and prenatal care because its future citizens who receive such care would be born healthier and have fewer expensive chronic illnesses. Fewer chronic illness among a population would have huge returns on the welfare state because fewer people would be utilizing it for expensive medical treatments. Though most medical professionals condemn the extreme act of denying care to pregnant women or infants (documented or not), the Dominican Republic and the United States have a popular politics that embraces this cruelty, despite the fact that both pride themselves on a multi-ethnic population. It is easy for policymakers to incriminate undocumented immigrants and claim that they are responsible for an illegitimate share of the consumption of the country's resources. Therefore, it seems likely that the host country's perceptions of immigrant natality and maternity help construct a negative image of the immigration "problem" in such a way that laws and policies are designed without accurate rationale. This thesis examines how the United States and the Dominican Republic might improve the relationship between the culture of healthcare and the role of the legal system for immigrants and their children. It seeks to understand the reasons, motivations, and consequences for denying immigrants services on the account of their citizenship status. The social, economic, and health consequences of being an undocumented citizen will be examined. Current legal policy and what political roadblocks and cultural prejudices must be overcome in order to implement a successful policy will be reviewed. Finally, the best practices prenatal care as a national investment will be discussed, as will the problem of cross-cultural perception of natality, maternity, and immigration.

This project is to help Guatemalan youth immigrants by providing them with the information necessary to access support in the United States, and obtainin legal status in the United States. In order to produce a brochure with this information, it was necessary to research the political, economic, and social history of Guatemala in order to determine what struggles citizens are facing, and specifically what experiences youth in the country have prior to their journey to the United States. This research is culminated into a paper that discusses the history, the causes of emigration from Guatemala, and the status of youth immigrants before they leave Guatemala and once they arrive in the United States.

In a cross memoir and essay format, I examine what connection barriers veterans face when communicating with civilians. I interviewed veterans after adapting an interview schedule and model release form. Additionally, I researched creative nonfiction, guided autobiography, and Posttraumatic Stress Disorder. I chose to focus mainly on soldiers returning from recent conflicts. Once I collected my interviews, I synthesized the stories I heard with personal memoir. The thesis focuses on three parts: coming home, communication barriers, and connection. Weaving in both my personal reflection and the voices of the soldiers I interviewed, I evaluate possible ways veterans and civilians fail to connect. I address the discrepancy between the apparent warm reception of soldiers and the feelings of disconnection soldiers express by noting the ways in which both the solider and the civilian struggle to communicate. Looking at reintegration struggles, I briefly note the transition difficulty post deployment soldiers face. From the responses I received, I reflect on how empty gestures, perceived ignorance, and an outsider effect contribute to communication barriers between soldiers and veterans. While I address how ignorance can be broken down into misunderstanding military jargon, detaching from war, hearing euphemisms, and having expectations, I also consider the ways in which situation and vagueness surrounding the war contribute to communication barriers surrounding perceived ignorance. From my reflection of communication barriers, I offer tools for soldiers and veterans making connections. I recommend that both soldiers and civilians stay informed about the military engagements as best they can, deconstruct expectations and generalizations, use empathy and active listening, and start being direct. Knowing the nuanced complexity of war and communication, I weave in my own reflections in contribution to the larger conversation.

This study identifies the factors impacting the growing HIV/AIDS epidemic among men who have sex with men (MSM) in the Philippines. Ten studies and three external reviews concerning HIV, MSM, and the HIV/AIDS epidemic in the Philippines and Southeast Asia from 2009 to 2015 were analyzed to find common patterns in the literature and identify the factors that impact the HIV prevalence among MSM in the Philippines. Secondary analysis of the literature identified the following as influencing factors: HIV prevalence patterns, the accessibility of HIV-related health education, the engagement of MSM in health-seeking behaviors related to HIV, perceptions of HIV risk among MSM, and the influence of culture and religion in the Philippines. These factors lead to an increase in the overall HIV prevalence among MSM in the Philippines by increasing the potential of HIV transmission among the community as a whole and increasing the vulnerability of individual MSM to HIV infection. These factors were also found to be interconnected, each having an impact on the other. The lack of sexual health education coupled with the barriers to HIV-related health care are especially prominent interconnected issues concerning the prevention of HIV transmission. There needs to be further research in investigating which specific barriers that prevent the engagement and retention of HIV positive men in the Philippines in HIV care and related services after diagnosis in order to reduce the overall population viral load of HIV-positive MSM. Examining the issues concerning engagement in health care among HIV positive MSM could aid in overcoming the barriers to health care faced by MSM as well as addressing the increasing HIV prevalence among MSM in the Philippines.

With divorce rates rising (Kennedy & Ruggles, 2014), it is important to consider the impact of parental marital status on children and adolescents. In this study, we looked at whether children's relationships with their parents differ based on their parents being married or divorced/separated. We hypothesized that a child's perceived relationship with their parents would be significantly influenced by parental marital status, such that those whose parents are divorced will demonstrate a negative relationship with the perception of their parents. Using data collected from the longitudinal New England Study of Suburban Youth (NESSY), we ran correlational analyses as well as an analysis of variance (ANOVA) to determine whether different aspects of attachment (Alienation, Communication, and Trust), measured with the Inventory of Parent and Peer Attachment \u2014 Revised for Children (IPPA-R) were significantly linked to parental marital status (Luthar & Barkin, 2012). Using our sample size of 489 students in the twelfth grade, we divided the groups into children with married parents (414) and children with divorced or separated parents (75). An ANOVA produced a significant difference between children's perceived relationship with their father and parental marital status; the adolescents' perception of the father's Alienation, Communication, and Trust were negatively associated with divorce. However, the child's perceived relationship with their mother was similar across both groups. These results suggest further research is needed to determine the effects of a child's perception of their relationship with their father during development, in particular in situations when parents have divorced before high school graduation.

There are problems in the breeding practices of miniature horses. This study seeks to determine the source of these detrimental outcomes based on an evaluation of primary attributes selected for by breeders and the lack of genetic information and understanding of these attributes. In order to do this a program model was created to test the effects of selection criteria on breeder behavior and the resultant foals of these crosses. Moving forwards this program will evolve into a database of the equine genome for different horses. This will allow breeders to input their horses and do faux crosses in order to decrease the incidence of negative and detrimental outcomes.