Coarse-Grained Reconfigurable Arrays (CGRAs) are emerging accelerators that promise low-power acceleration of compute-intensive loops in applications. The acceleration achieved by CGRA relies on the efficient mapping of the compute-intensive loops by the CGRA compiler onto the CGRA. The CGRA mapping problem, being NP-complete, is performed in a two-step process, scheduling, and mapping. The scheduling algorithm allocates timeslots to the nodes of the DFG, and the mapping algorithm maps the scheduled nodes onto the PEs of the CGRA. On a mapping failure, the initiation interval (II) is increased, and a new schedule is obtained for the increased II. Most previous mapping techniques use the Iterative Modulo Scheduling algorithm (IMS) to find a schedule for a given II. Since IMS generates a resource-constrained ASAP (as-soon-as-possible) scheduling, even with increased II, it tends to generate a similar schedule that is not mappable and does not explore the schedule space effectively. The problems encountered by IMS-based scheduling algorithms are explored and an improved randomized scheduling algorithm for scheduling of the application loop to be accelerated is proposed. When encountering a mapping failure for a given schedule, existing mapping algorithms either exit and retry the mapping anew, or recursively remove the previously mapped node to find a valid mapping (backtrack).Abandoning the mapping is extreme, but even backtracking may not be the best choice, since the root of the problem may not be the previous node. The challenges in existing algorithms are systematically analyzed and a failure-aware mapping algorithm is presented. The loops in general-purpose applications are often complicated loops, i.e., loops with perfect and imperfect nests and loops with nested if-then-else's (conditionals). The existing hardware-software solutions to execute branches and conditions are inefficient. A co-design approach that efficiently executes complicated loops on CGRA is proposed. The compiler transforms complex loops, maps them to the CGRA, and lays them out in the memory in a specific manner, such that the hardware can fetch and execute the instructions from the right path at runtime. Finally, a CGRA compilation simulator open-source framework is presented. This open-source CGRA simulation framework is based on LLVM and gem5 to extract the loop, map them onto the CGRA architecture, and execute them as a co-processor to an ARM CPU.