Short-notice disasters such as hurricanes involve uncertainties in many facets, from the time of its occurrence to its impacts’ magnitude. Failure to incorporate these uncertainties can affect the effectiveness of the emergency responses. In the case of a hurricane event, uncertainties and corresponding impacts during a storm event can quickly cascade. Over the past decades, various storm forecast models have been developed to predict the storm uncertainties; however, access to the usage of these models is limited. Hence, as the first part of this research, a data-driven simulation model is developed with aim to generate spatial-temporal storm predicted hazards for each possible hurricane track modeled. The simulation model identifies a means to represent uncertainty in storm’s movement and its associated potential hazards in the form of probabilistic scenarios tree where each branch is associated with scenario-level storm track and weather profile. Storm hazards, such as strong winds, torrential rain, and storm surges, can inflict significant damage on the road network and affect the population’s ability to move during the storm event. A cascading network failure algorithm is introduced in the second part of the research. The algorithm takes the scenario-level storm hazards to predict uncertainties in mobility states over the storm event. In the third part of the research, a methodology is proposed to generate a sequence of actions that simultaneously solve the evacuation flow scheduling and suggested routes which minimize the total flow time, or the makespan, for the evacuation process from origins to destinations in the resulting stochastic time-dependent network. The methodology is implemented for the 2017 Hurricane Irma case study to recommend an evacuation policy for Manatee County, FL. The results are compared with evacuation plans for assumed scenarios; the research suggests that evacuation recommendations that are based on single scenarios reduce the effectiveness of the evacuation procedure. The overall contributions of the research presented here are new methodologies to: (1) predict and visualize the spatial-temporal impacts of an oncoming storm event, (2) predict uncertainties in the impacts to transportation infrastructure and mobility, and (3) determine the quickest evacuation schedule and routes under the uncertainties within the resulting stochastic transportation networks.