The purpose of this study was to gain an understanding of the lives of highly educated Navajo women who, with their children, left the comfort of their homeland to pursue their careers. Using qualitative research methods, five Navajo women were asked to reflect on their lives while on the reservation and in their new location off the Navajo reservation. Among the topics explored were the principal factors as to their leaving the reservation, barriers and supports they faced in their careers, what cultural transitions they experienced, and the effects on their careers, their families and to their personal sense of self.