Culture played an intrinsic role in the conquest of Ireland in the sixteenth century, and the English colonial project, so often described in political and military terms, must be reexamined in this context. By examining sixteenth century spatial and literary representations of Ireland and Irish culture it becomes evident that the process described by Timothy Mitchell, called enframement, was being imposed upon the Irish. Enframement is the convergence of two aspects of power, the metaphysical and the microphysical. Metaphysical power worked through maps and literature to bring order in the conceptual realm, allowing the English to imagine Ireland as they wished it to be. Microphysical power created order in the material world, by physically changing the appearance of the landscape and people to conform to England's laws and norms. The English justified their policy of colonization by representing Ireland and Gaelic culture as wild or barbarous, and hoped to achieve their colonial ambition by physically coercing the Irish into adopting the "superior" English culture.

When the Irish continued to rebel against English rule, the colonizers began employing methods of extreme violence to subdue the Gaelic people. At the same time, they began to practice more extreme forms of cultural colonization by attacking those aspects of Gaelic culture which most resisted conformity to English standards of civility. The Gaelic legal system, called Brehon law, redistributive inheritance, cattle herding and traditional forms of Irish dress were denigrated to assert English authority over the Irish people. English fear of the negative effects of Gaelic culture were exemplified by the Anglo-Irish lords, who were originally of English descent, but had "degenerated" into Irish barbarians through the use of Gaelic culture. This retrograde process could also occurred when an English person practiced marriage, childbirth, wet-nursing or fosterage with Irish persons. These interactions, and the consequences which came from them, were often described in terms of infection and disease. Thus culture, operating on multiple levels, and how that culture was represented, became a powerful site for colonial power to operate.