Development of a Terpene Cyclase Using Oxyanion Hole Biocatalysis
Description
Terpene cyclizations are one of the most complex reactions that occur in nature. Scientists have found that replicating this reaction in a lab setting has proved to be immensely challenging as result of the numerous intermediates that must be controlled through the cyclization process in the absence of an enzyme. This study uses commercially available lipases to conduct reactions with geraniol-derived starting materials to identify conditions for performing a terpene cyclization effectively and efficiently. Through hypothesized screening of enzymes and reaction conditions, we have identified a protocol for the successful cyclization of limonene and other geranyl-derived products.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2021-05
Agent
- Author (aut): Gupta, Ritika
- Thesis director: Biegasiewicz, Kyle
- Committee member: Ackerman-Biegasiewicz, Laura
- Committee member: Heyden, Matthias
- Contributor (ctb): College of Health Solutions
- Contributor (ctb): Barrett, The Honors College