The aim of this paper is to empower musicians with the knowledge and tools to address the challenges of music performance anxiety (MPA) with confidence and efficacy. Three evidence-based concepts will be examined, beginning with neuroplasticity, which is the brain’s capacity to change both structurally and functionally. It is thus in a constant state of evolution. On the functional side, evidence demonstrates that it is possible for individuals to change the way they think in order to provide more positive outcomes in music performance. Secondly, existing literature on the cognitive side of learning and optimal performance will be examined; particularly, flow theory of Mihaly Csikszentmihalyi (1975) and Carol Dweck’s mindset theory (2006). Finally, a review of sports psychology research on mental imagery will be provided. For each area of research, I will suggest strategies with which musicians may incorporate these theories in their own practice and performance in order to develop a growth mindset, alter their negative thought patterns, and overcome MPA, achieving their optimal performance level.