Easily deliverable and elastic thermosensitive physical-chemical gelling hydrogels for embolization
Description
Rupture of intracranial aneurysms causes a subarachnoid hemorrhage, which is often lethal health event. A minimally invasive method of solving this problem may involve a material, which can be administered as a liquid and then becomes a strong solid within minutes preventing flow of blood in the aneurysm. Here we report on the development of temperature responsive copolymers, which are deliverable through a microcatheter at body temperature and then rapidly cure to form a highly elastic hydrogel. To our knowledge, this is the first physical-and chemical-crosslinked hydrogel capable of rapid crosslinking at temperatures above the gel transition temperature. The polymer system, poly(N-isopropylacrylamide-co-cysteamine-co-Jeffamine® M-1000 acrylamide) and poly(ethylene glycol) diacrylate, was evaluated in wide-neck aneurysm flow models to evaluate the stability of the hydrogels. Investigation of this polymer system indicates that the Jeffamine® M-1000 causes the gels to retain water, resulting in gels that are initially weak and viscous, but become stronger and more elastic after chemical crosslinking.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2013-05
Agent
- Author (aut): Lee, Elizabeth Jean
- Thesis director: Vernon, Brent
- Committee member: Brennecka, Celeste
- Committee member: Overstreet, Derek
- Contributor (ctb): Barrett, The Honors College
- Contributor (ctb): School of Mathematical and Statistical Sciences