Application of TMPP Labeling and Ammonia Gas Cleavage in MALDI-MS Analysis of Resin-bound Peptides
Description
One of the major challenges that were yet to be solved for solid phase peptide synthesis was the lack of an efficient peptide sequencing technique that was less hazardous, easier to perform , and was more cost-effective. Sequencing peptides were held important in the field of Chemistry and Biochemistry because it aided in drug discovery, finding ligands that bind to a specific target protein and finding alternative agents in transporting molecules to its desired location. Therefore, the overall purpose of this experiment was to develop a method of solid phase sequencing technique that was more environmental friendly, sequences at a faster rate, and was more cost-effective.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2014-05
Agent
- Author (aut): Cordovez, Lalaine Anne Ordiz
- Thesis director: Woodbury, Neal
- Committee member: Zhao, Zhan-Gong
- Committee member: Legutki, Joseph Barten
- Contributor (ctb): Barrett, The Honors College
- Contributor (ctb): Department of Chemistry and Biochemistry