As a result of the increase of pollution related to industrialization in Vietnam, acid rain has become a prevalent issue for Vietnamese farmers who are forced to rinse their crops – risking damage due to overwatering and poor harvest. Thus, the team was motivated to develop a solution to harmful impacts of acidic rainwater by creating a system with the ability to capture rainwater and determine its level of acidity in order to optimize the crop watering process, and promote productive crops. By conducting preliminary research on rainfall and tropical climate in Vietnam, existing products on the market, and pH sensors for monitoring and device material, the team was able to design a number of devices to collect, store, and measure the pH of rainwater. After developing a number of initial design requirements based on the needs of the farmers, a final prototype was developed using the best aspects of each initial design. Tests were conducted with varying structural and aqueous materials to represent a broad range of environmental conditions. While the scope of the project was ultimately limited to prototyping purposes, the principles explored throughout this thesis project can successfully be applied to a fully-functioning production model available for commercial use on Vietnamese farms. Given more time for development, improvements would be made in the extent of materials tested, and the configuration of electronics and data acquisition, in order to further optimize the process of determining rainwater acidity.

As a result of the increase of pollution related to industrialization in Vietnam, acid rain has become a prevalent issue for Vietnamese farmers who are forced to rinse their crops – risking damage due to overwatering and poor harvest. Thus, the team was motivated to develop a solution to harmful impacts of acidic rainwater by creating a system with the ability to capture rainwater and determine its level of acidity in order to optimize the crop watering process, and promote productive crops. By conducting preliminary research on rainfall and tropical climate in Vietnam, existing products on the market, and pH sensors for monitoring and device material, the team was able to design a number of devices to collect, store, and measure the pH of rainwater. After developing a number of initial design requirements based on the needs of the farmers, a final prototype was developed using the best aspects of each initial design. Tests were conducted with varying structural and aqueous materials to represent a broad range of environmental conditions. While the scope of the project was ultimately limited to prototyping purposes, the principles explored throughout this thesis project can successfully be applied to a fully-functioning production model available for commercial use on Vietnamese farms. Given more time for development, improvements would be made in the extent of materials tested, and the configuration of electronics and data acquisition, in order to further optimize the process of determining rainwater acidity.

As a result of the increase of pollution related to industrialization in Vietnam, acid rain has become a prevalent issue for Vietnamese farmers who are forced to rinse their crops – risking damage due to overwatering and poor harvest. Thus, the team was motivated to develop a solution to harmful impacts of acidic rainwater by creating a system with the ability to capture rainwater and determine its level of acidity in order to optimize the crop watering process, and promote productive crops. By conducting preliminary research on rainfall and tropical climate in Vietnam, existing products on the market, and pH sensors for monitoring and device material, the team was able to design a number of devices to collect, store, and measure the pH of rainwater. After developing a number of initial design requirements based on the needs of the farmers, a final prototype was developed using the best aspects of each initial design. Tests were conducted with varying structural and aqueous materials to represent a broad range of environmental conditions. While the scope of the project was ultimately limited to prototyping purposes, the principles explored throughout this thesis project can successfully be applied to a fully-functioning production model available for commercial use on Vietnamese farms. Given more time for development, improvements would be made in the extent of materials tested, and the configuration of electronics and data acquisition, in order to further optimize the process of determining rainwater acidity.

3D printing prosthetics for amputees is an innovative opportunity to provide a lower cost and customized alternative to current technologies. Companies, such as E-NABLE and YouBionic are developing myoelectric prosthetics, electrically powered terminal devices activated by electromyography (EMG), for transradial amputees. Prosthetics that are 3D printed are less expensive for juvenile use, more sustainable, and more accessible for those without insurance. Although they are typically not outfitted with the same complex grip patterns or durability of a traditional myoelectric prosthetic, they offer a sufficient durability (withstanding up to 150 N on average) and allow for new opportunities in prosthetic development. Devils Prosthetics, a student research and development group associated with Engineering Projects in Community Service (EPICS), has investigated the benefits and pitfalls of utilizing polyethylene terephthalate glycol (PETG) for 3D printing prosthetics as well as combining a MyoWare EMG sensor with machine learning for optimal control of the prosthetic.

The EPICS program, an acronym for Engineering Projects in Community Service, provides students an opportunity to create engineering solutions to “real world” problems. This honors thesis project is a collaboration with the EPICS program, the Vietnam Smart Agriculture EPICS team, and the Da Nang University of Technology (DUT) in Da Nang, Vietnam. The goal of the Vietnam Smart Agriculture EPICS team is to design an accessible system to reduce water consumption for Vietnamese small farmers through the use of smart agriculture technology. In January of 2023, my EPICS team and I were able to travel and interview five farmers in the Tra Que Farm to complete a needs assessment. The focus of this thesis project is to provide background research and to complete a feasibility study to aid the Vietnam Smart Agriculture EPICS team in developing a smart agriculture device to aid small farmers with overwatering. The thesis includes a literature review investigating solutions for evaluating the water needs of crops, delves into insights gathered from interviews with Vietnamese small farmers, and data collected from their farms.

3D printing prosthetics for amputees is an innovative opportunity to provide a lower cost and customized alternative to current technologies. Companies, such as E-NABLE and YouBionic are developing myoelectric prosthetics, electrically powered terminal devices activated by electromyography (EMG), for transradial amputees. Prosthetics that are 3D printed are less expensive for juvenile use, more sustainable, and more accessible for those without insurance. Although they are typically not outfitted with the same complex grip patterns or durability of a traditional myoelectric prosthetic, they offer a sufficient durability (withstanding up to 150 N on average) and allow for new opportunities in prosthetic development. Devils Prosthetics, a student research and development group associated with Engineering Projects in Community Service (EPICS), has investigated the benefits and pitfalls of utilizing polyethylene terephthalate glycol (PETG) for 3D printing prosthetics as well as combining a MyoWare EMG sensor with machine learning for optimal control of the prosthetic.

This honors thesis proposes a sustainable solution for providing off-grid solar energy to rural communities lacking grid energy infrastructure. The proposed design emphasizes sustainability, low cost, reliability, and ease of maintenance and manufacturing. The report compares pre-built solar systems currently available for purchase with the proposed design. The project includes a user manual draft to ensure long-term sustainability and troubleshooting. Additionally, there is a detailed engineering design for a battery storage solution, electrical component design, and solar panel mounting system. A rural community in northern Arizona serves as an example for the project completed in collaboration with ASU's EPICS program and EWB Chapter. The project is ongoing, with future work to optimize and improve the proposed system design.

This honors thesis proposes a sustainable solution for providing off-grid solar energy to rural communities lacking grid energy infrastructure. The proposed design emphasizes sustainability, low cost, reliability, and ease of maintenance and manufacturing. The report compares pre-built solar systems currently available for purchase with the proposed design. The project includes a user manual draft to ensure long-term sustainability and troubleshooting. Additionally, there is a detailed engineering design for a battery storage solution, electrical component design, and solar panel mounting system. A rural community in northern Arizona serves as an example for the project completed in collaboration with ASU's EPICS program and EWB Chapter. The project is ongoing, with future work to optimize and improve the proposed system design.

This honors thesis report aims to propose a sustainable long-term solution for providing off-grid solar energy to rural communities that lack the necessary grid energy infrastructure. With this in mind, we aim to establish the framework and documentation for people to be able to build and maintain their own off-grid solar power systems. Due to recent incentives for clean energy both nationwide and statewide, the team will discuss the current renewable energy market and the future growth potential of residential solar energy systems, which includes off-grid or remote solar. This discussion will include comparing pre-built solar systems currently offered for purchase against the proposed design outlined in this report. Notably, the outlined design has been made with an emphasis on system sustainability, low initial cost, reliability, ease of manufacturing/maintenance, and material selection. Lastly, the team will discuss the project’s approach to documentation with a user manual draft to ensure the system's long-term sustainability and troubleshooting. Although the efforts of this project have increased over time, this project remains active within the ASU EWB chapter, meaning that not all aspects described throughout this report are fully complete as future work will continue to optimize and improve the system. A rural community in northern Arizona, will be used as an example to understand a rural community's needs for designing a solar panel system that provides sufficient energy for a single household. The project was completed in collaboration with Arizona State University’s Engineering Projects In Community Service (EPICS) program and Engineers Without Borders (EWB) chapter. Both these organizations aim to connect ASU students to the professional mentors and resources they need to design and implement low-cost, small-scale, easily replicated, and sustainable engineering projects.

Aminoglycosides contain a basic unit of an amino-modified glycoside (sugar) and have potent antibacterial properties used to treat a wide range of bacterial infections, including those that occur in the soft tissue, chest, urinary tract, and endocardial tissue.1, 2 With a broad spectrum of activity and convenient dosing schedule, Aminoglycoside helps to effectively fight off Gram-negative bacteria.1, 3 In 1944 an aminoglycoside called streptomycin entered clinical trials to test its effectiveness as an antibiotic.4 After several years other classes of aminoglycosides were discovered such as neomycin, gentamicin, kanamycin, and netilmicin.4 When introduced these antibiotics presented major clinical advancements in the treatment of Tuberculosis and other bacterial infections.3, 4 However their use in modern medicine has diminished due to their toxicity, required parenteral delivery, and the availability of alternative antibiotics.3, 5 The dose-dependent toxicity of aminoglycosides limits their use due to a narrow range of safe aminoglycoside plasma concentrations.3, 5 Exceeding this range in non-target tissues can lead to negative effects on the audio-vestibular apparatus and kidneys.3, 5, 6 In the 1980’s, clinicians began treating infections with antibiotics that were perceived as less toxic and providing broader antibacterial activity.7 This resulted in aminoglycosides being prescribed for more persistent infections that were resistant to other antibiotics.3 With the amount of antibiotic resistant bacteria increasing, many scientists have begun looking into methods for minimizing aminoglycoside toxicity and maximizing its antibacterial activity.3, 8 These methods include encapsulation and polymer conjugation.9, 10 By encapsulating aminoglycosides in liposomes or other vesicles scientists aim to increase its concentration in infected tissues while decreasing nephro- and ototoxicity.9 With conjugated polymers scientists have created polymer complexes containing aminoglycosides and other compounds such as dopamine.11 The goal of these polymers is to limit toxicity by slowing antibiotic release and increasing efficacy of the antibiotic through targeted delivery and toxicity of other compounds.9, 10, 11 Other than its use in treating infections, aminoglycosides are gaining attention as an excellent vehicle for gene delivery.12 In this application aminoglycosides are used to correct a genetic defect by introducing a normal copy of the gene into affected cells.12,13 Currently scientists are assessing aminoglycosides for gene therapy in the treatment of cancer and various other diseases.12, 14 This review will focus on the diverse customizability of aminoglycosides in treating infections and as vehicles for gene therapy.