Reconfigurable metasurfaces (RMSs) are promising solutions for beamforming and sensing applications including 5G and beyond wireless communications, satellite and radar systems, and biomarker sensing. In this work, three distinct RMS architectures – reconfigurable intelligent surfaces (RISs), meta-transmission lines (meta-TLs), and substrate integrated waveguide leaky-wave antennas (SIW-LWAs) are developed and characterized. The ever-increasing demand for higher data rates and lower latencies has propelled the telecommunications industry to adopt higher frequencies for 5G and beyond wireless communications. However, this transition to higher frequencies introduces challenges in terms of signal coverage and path loss. Many base stations would be necessary to ensure signal fidelity in such a setting, making bulky phased array-based solutions impractical. Consequently, to meet the unique needs of 5G and beyond wireless communication networks, this work proposes the use of RISs characterized by low-profile, low-RF losses, low-power consumption, and high-gain capabilities, making them excellent candidates for future wireless communication applications. Specifically, RISs at sub-6GHz, mmWave and sub-THz frequencies are analyzed to demonstrate their ability to improve signal strength and coverage. Further, a linear meta-TL wave space is designed to achieve miniaturization of true-time delay beamforming structures such as Rotman lenses which are traditionally bulky. To address this challenge, a modified lumped element TL model is proposed. A meta-TL is created by including the mutual coupling effects and can be used to slow down the electromagnetic signal and realize miniaturized lenses. A proof-of-concept 1D meta-TL is developed to demonstrate about 90% size reduction and 40% bandwidth improvement. Furthermore, a conformable antenna design for radio frequency-based tracking of hand gestures is also detailed. SIW-LWA is employed as the radiating element to couple RF signals into the human hand. The antenna is envisaged to be integrated in a wristband topology and capture the changes in the electric field caused by various movements of the hand. The scattering parameters are used to track the changes in the wrist anatomy. Sensor characterization showed significant sensitivity suppression due to lossy multi-dielectric nature tissues in the wrist. However, the sensor demonstrates good coupling of electromagnetic energy making it suitable for on-body wireless communications and magnetic resonance imaging applications.