The roles of American Universities/colleges assets, knowledge and partnerships with local governments during disasters and emergencies become more important but have not been emphasized sufficiently in the scholarship community. Universities/colleges have provided disaster services in partnership with local government through different ways: providing facilities and logistical support (e.g., disaster sheltering), critical knowledge support (e.g., disaster information forecasting), and human resources and special expertise support (e.g., university hospitals and voluntary work of nursing and medical students/faculty). Through 34 interviews with emergency managers from both universities/colleges and local governments, and a national survey of 362 university emergency managers, this dissertation finds that: First, previously established partnerships between universities/colleges and local governments can reduce coordination costs when disasters happen and can facilitate new partnerships on disaster preparedness. Second, local government capacity gap in responding to disaster needs is a critical precondition for universities/colleges to participate in the disaster service co-provision, which is not specified or examined by other co-production, co-creation, or co-management theories. Third, internal coordination efforts within universities/colleges can facilitate external coordination activities with local governments to guarantee efficient disaster service provision. Fourth, a disaster resilience culture needs to be facilitated within universities/colleges to develop a robust disaster response plan. Furthermore, first response providers’ health and wellbeing should get more attention from universities and local governments to maintain a sustainable and healthy workforce as well as efficient disaster response.