This study draws upon original data to identify protective factors of resilience among Indigenous college students who experience victimization with the goal of facilitating safety and health. The data draws from 16 interviews and 95 surveys with Indigenous college students about their victimization, including their experiences with the global issue of Missing and Murdered Indigenous Peoples (MMIP). This research uses a decolonizing methodology, a trauma-informed approach, and a human-centered design while incorporating aspects of community-based participatory research with Indigenous populations. Many participants experienced at least one form of victimization (82%), and nearly all (94%) were aware of the MMIP crisis. Interviews revealed that MMIP had an emotional, psychological, and social impact on students regardless of their relationship with a victim. Participants identified several protective factors that enhanced their resilience, including reclaiming identity, reciprocity, taking healing actions, self-reflection, taking healthy risks, having goals, being with their community and their family, and having courage and strength. These findings provide support for five culturally appropriate university policy recommendations to enhance Indigenous students’ resilience through culturally-competent programming, evaluation, and training.