For African countries during the 1960s and 70s, decolonization marked the first step in a slow crawl toward complete independence. For Western powers and the Soviet Union, however, decolonization presented an opportunity to exert new influence over countries in desperate need of aid, investment, experts, and trade. Amidst the backdrop of increasing Cold War tensions, the US and USSR used foreign aid to pressure development according to either capitalist or Marxist agendas. Thus, sub-Saharan Africa became a battleground of proxy wars and neocolonialism. The Cold War superpowers would back opposing regimes in Angola and prop up, oust, or assassinate leaders in Ghana, Democratic Republic of the Congo, and Tanzania. This disrupted natural political development and created instability and violence, which was compounded by the arrival of the AIDS epidemic in the mid-1980s. AIDS ravaged African societies and destroyed the remaining fibers of leadership. The disease illuminated harsh historical realities as it spread among the conflict-stricken countries of sub-Saharan Africa. The goal of this thesis is to analyze the motivations behind US and USSR foreign aid during the Cold War, understand how their involvement halted the natural progression of pan-Africanism and leadership in newly-independent African countries, and link the resulting violence to the devastation of the AIDS crisis twenty years later. It begins with a look at European colonization in sub-Saharan Africa and traces the legacy of western influence in the region. The paper will then analyze specific examples of the consequences of historical interference, such as in the Angolan Civil War, the Congo Crisis, and the Rwandan genocide. It will introduce the AIDS crisis—coincident with major civil conflict and the end of the Cold War—and reveal the foreign aid response of the international community in the late 1990s and early 2000s, once Cold War-era pressures were gone. Through realizing the continued impact and spread of HIV/AIDS, the objective of this paper is to present a comprehensive view of the modern-day consequences of historical interference.