Despite an increasing number of women completing doctoral programs each year, there remains a deficit in the representation of women in the fields of science, technology, engineering, and mathematics (STEM). Moreover, Women of Color (WoC) in STEM doctoral programs face unique stressors and barriers that their male colleagues may not, such as microaggressions, racism, and sexism due to their marginalized identities. Although there is a growing body of research focusing on how WoC in STEM successfully navigate academic challenges and symptoms of distress present in rigorous doctoral training, there is limited research examining intrapersonal (i.e., academic resilience) and interpersonal (i.e., perceived social support) factors that may mitigate the negative associations of these experiences. To address these gaps in the literature, the present study gathered data from 174 WoC during December 2021 and January 2022. Results supported the hypothesis that academic challenges would be positively associated with symptoms of distress. Furthermore, based on research showing positive associations between both academic resilience and social support and psychological well-being, the study also examined whether academic resilience and perceived social support from friends and romantic partners. While academic resilience was not found to moderate the association between academic challenges and symptoms of distress, perceived social support was found to have moderating effects, such that low and high levels of perceived social support increased the strength of the positive association between academic challenges and symptoms of distress. Results of the present study have implications for doctoral programs and mental health practitioners working at university college centers and support for need for the enhancement of the structure and process of the doctoral program experience for WoC in STEM.