Prenatal Maternal Stress Alters Alzheimer’s Disease Pathology in 12-Month Old 3xTg Alzheimer’s Disease Mouse Model
Description
Alzheimer’s Disease (AD) is the most prevalent form of dementia and is the sixth leading cause of death in the elderly. Evidence suggests that forms of stress, including prenatal maternal stress (PMS), could exacerbate AD development. To better understand the mechanism linking PMS and AD, we investigated behavior and specific epigenetic markers of the 3xTg-AD mouse model compared to aged-controls in offspring of stressed mothers and non-stressed mothers.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2022-12
Agent
- Author (aut): Brookhouser, Leia
- Thesis director: Coleman, Paul
- Committee member: Velazquez, Ramon
- Committee member: Conrad, Cheryl
- Committee member: Judd, Jessica
- Contributor (ctb): Barrett, The Honors College
- Contributor (ctb): Department of Psychology