Although adverse events cannot always be prevented, the negative outcomes on development can potentially be modified by considering methods of fostering positive emotional and behavioral responses. The study examined biopsychosocial health outcomes in the presence of uncontrollable adverse childhood events with the goal of identifying a potential intervention to increase resilience, health, and safe behaviors among at-risk children. It was hypothesized that adverse events can result in positive biopsychosocial outcomes in the presence of high scores on the Positive Emotion, Engagement, Relationships, Meaning, and Accomplishments (PERMA) model of well-being, self-efficacy, gratitude, and the ability to envision a positive future self. The study retrospectively examined adverse childhood events and present behavioral, emotional, and physical health outcomes. Participant (n = 685) data were analyzed using Hayes PROCESS (v3.5) to test all components of the moderation model. Results suggest that as adverse events increase, health adversity also increases. However, those with high intrapersonal strengths showed better health outcomes. Through understanding intrapersonal pathways in the presence of adverse events, the study can potentially identify mechanisms important for promoting resilient outcomes in childhood that could cascade into adulthood.