The United States has historically been perceived as a “nation of immigrants'' dueto its eclectic racial and ethnic make-up. Nonetheless, the nation’s relationship and attitudes towards immigrants have been predominantly negative, especially with Latinx immigrants. The criminalization of Latinx immigration has led to an array of poor psychosocial outcomes for those who arrive and remain within the United States. Numerous studies have found a significant positive relationship between discrimination and elevated rates of depression, anxiety, and stress among Latinx immigrants. Seeing that Latinxs are projected to become 25% of the U.S. population by 2060, there is an urgent need for the development of culturally-affirming interventions grounded on protective factors unique to this population. This study sought to expand on the current literature surrounding the relationship between discrimination and poor mental health outcomes in Latinx immigrants, by determining whether hope and optimism serve as protective factors. Findings from a multi-step linear regression analysis showed that hope and optimism do have a significant moderation effect on Latinx mental health outcomes. Nonetheless, results varied by gender and mental health construct between depression, anxiety, and stress. The findings from this study provide an additional antidote for ameliorating the pernicious effects of discrimination concerning this cultural group. Recommendations informed by these findings are made for social work practice, policy reform, and research.