Science is a formalized method for acquiring information about the world. In

recent years, the ability of science to do so has been scrutinized. Attempts to reproduce

findings in diverse fields demonstrate that many results are unreliable and do not

generalize across contexts. In response to these concerns, many proposals for reform have

emerged. Although promising, such reforms have not addressed all aspects of scientific

practice. In the social sciences, two such aspects are the diversity of study participants

and incentive structures. Most efforts to improve scientific practice focus on replicability,

but sidestep issues of generalizability. And while researchers have speculated about the

effects of incentive structures, there is little systematic study of these hypotheses. This

dissertation takes one step towards filling these gaps. Chapter 1 presents a cross-cultural

study of social discounting – the purportedly fundamental human tendency to sacrifice

more for socially-close individuals – conducted among three diverse populations (U.S.,

rural Indonesia, rural Bangladesh). This study finds no independent effect of social

distance on generosity among Indonesian and Bangladeshi participants, providing

evidence against the hypothesis that social discounting is universal. It also illustrates the

importance of studying diverse human populations for developing generalizable theories

of human nature. Chapter 2 presents a laboratory experiment with undergraduates to test

the effect of incentive structures on research accuracy, in an instantiation of the scientific

process where the key decision is how much data to collect before submitting one’s

findings. The results demonstrate that rewarding novel findings causes respondents to

make guesses with less information, thereby reducing their accuracy. Chapter 3 presents

an evolutionary agent-based model that tests the effect of competition for novel findings

on the sample size of studies that researchers conduct. This model demonstrates that

competition for novelty causes the cultural evolution of research with smaller sample

sizes and lower statistical power. However, increasing the startup costs to conducting

single studies can reduce the negative effects of competition, as can rewarding

publication of secondary findings. These combined chapters provide evidence that

aspects of current scientific practice may be detrimental to the reliability and

generalizability of research and point to potential solutions.