This thesis work present the simulation of Bluetooth and Wi-Fi radios in real life interference environments. When information is transmitted via communication channels, data may get corrupted due to noise and other channel discrepancies. In order to receive the information safely and correctly, error correction coding schemes are generally employed during the design of communication systems. Usually the simulations of wireless communication systems are done in such a way that they focus on some aspect of communications and neglect the others. The simulators available currently will either do network layer simulations or physical layer level simulations. In many situations, simulations are required which show inter-layer aspects of communication systems. For all such scenarios, a simulation environment, WiscaComm which is based on time-domain samples is built. WiscaComm allows the study of network and physical layer interactions in detail. The advantage of time domain sampling is that it allows the simulation of different radios together which is better than the complex baseband representation of symbols. The environment also supports study of multiple protocols operating simultaneously, which is of increasing importance in today's environment.