This thesis explores the impact of different experimental design strategies for the development of quantile regression based metamodels of computer simulations. In this research, the objective is to compare the resulting predictive accuracy of five experimental design strategies, each of which is used to develop metamodels of a computer simulation of a semiconductor manufacturing facility. The five examined experimental design strategies include two traditional experimental design strategies, sphere packing and I-optimal, along with three hybrid design strategies, which were developed for this research and combine desirable properties from each of the more traditional approaches. The three hybrid design strategies are: arbitrary, centroid clustering, and clustering hybrid. Each of these strategies is analyzed and compared based on common experimental design space, which includes the investigation of four densities of design point placements three different experimental regions to predict four different percentiles from the cycle time distribution of a semiconductor manufacturing facility. Results confirm that the predictive accuracy of quantile regression metamodels depends on both the location and density of the design points placed in the experimental region. They also show that the sphere packing design strategy has the best overall performance in terms of predictive accuracy. However, the centroid clustering hybrid design strategy, developed for this research, has the best predictive accuracy for cases in which only a small number of simulation resources are available from which to develop a quantile regression metamodel.