General Strain Theory (GST) posits that different types of strain lead to different types of negative emotions, some of which increase the likelihood of maladaptive coping. Much research on GST has focused on anger and depression. Far less attention has been directed toward other negative emotions, including anxiety and envy. The current study uses cross-sectional data from surveys administered to a university-based sample (N = 500) to address these voids and explore gender differences in the effects of strain and negative emotions in maladaptive coping. Results indicate that when gender differences existed in levels of strain and negative emotions, females experienced higher levels than males. Strain significantly predicted all four measures of negative emotions examined in this study. Finally, different negative emotions were found to have differing effects on different measures of maladaptive coping. Implications of this study for theory, future research, and policy are discussed.