Buildings and other structures, all components and cladding thereof, shall be designed and constructed to resist the wind loads are required in all wind codes. Simple quasi-static treatment of wind loads, which is universally applied to design of low to medium-rise structures, can be either overly conservative or erroneous under-estimated for design of high-rise structures. Dynamic response, vortex, wind directionality, and shedding from other structures are all complicated key factors suppose to be considered in design. Meanwhile, wind tunnel testing is expansive, difficult and sometimes inaccurate even if it is a widely used method in simulation of aerodynamic response. Computational Fluid dynamics (CFD), historically, were two-dimensional (2D) method using conformal transformations of the flow about a cylinder to the flow about an airfoil were developed in the 1930s. A number of three-dimensional (3D) codes were developed, leading to numerous commercial packages, which is more accessible and economical for wind load analysis.