Using an integrated perspective of the Grief Work Hypothesis and Posttraumatic Growth Theory, this study was designed to contribute to the sparse existing cross-cultural research by examining and comparing individuals' emotional adjustment and posttraumatic growth in the United States (US) and China. Another main goal was to unfold the predictive effects of different dimensions of locus of control, coping strategies and social support on the outcomes and further, to explore cultural differences in the underlying mechanisms. Web-based survey was disseminated and administered in the US and China. One thousand and seventy-eight participants completed the survey and met the criteria such that they were eighteen years old or older and experienced death of a loved one six to thirty-six months ago. As expected, US participants experienced higher levels of subjective well-being, lower levels of complicated grief and posttraumatic growth than Chinese participants. They also reported higher external yet lower internal locus of control, less frequent use of active and avoidance coping, and less informational support and negative social interactions than their Chinese counterparts. No difference in emotional support was evidenced between the two cultures. After controlling for demographic, loss-related information and the impact of post-bereavement life events, hierarchical regression analyses revealed that culture, external locus of control, avoidance coping and negative social interactions were unique predictors of complicated grief. Furthermore, the relation between external locus of control and complicated grief was weaker for US participants compared to that for Chinese participants. Culture, external and internal locus of control, active and avoidance coping, and negative social interactions significantly predicted individuals' subjective well-being after the loss. Additionally, culture, internal locus of control, active and avoidance coping, informational support, and negative social interactions were identified as unique predictors of posttraumatic growth. Specifically, an interaction effect of avoidance coping x culture emerged such that avoidance coping significantly predicted posttraumatic growth only for US participants. This study extracted the underlying mechanisms of predicting individuals' emotional adjustment and personal growth following bereavement. The influence of culture was also highlighted. Application of existing theories to the Chinese culture and clinical implications of the current study were discussed.