The purpose of this pilot study was to determine the impact of a theory-based manualized intervention to improve the mental health/coping outcomes of mothers of children newly diagnosed with cancer and their children. The primary aim of this pilot study was to assess the feasibility (timing, format, and length), acceptability (content and general acceptability) and preliminary effects of a three-phase manualized educational/skills building intervention with mothers of children newly diagnosed with cancer (i.e., COPE-PCC). Outcome measures included maternal depression and anxiety, and internalizing and externalizing behaviors in the child with cancer. Maternal beliefs about their ability to parent a child with cancer was a proposed mediator for this study.