Hydrothermal systems are not the typical environments in which organic chemistry is studied. However the organic reactions happening there are increasingly implicated in non-trivial geochemical processes. For example, the origins of life, the formation and degradation of petroleum, and feeding the deep biosphere. These are environments where water is heated and pressurized until it has a polarity more typical of an organic solvent and an increased dissociation constant that decreases its pH. In addition, these environments host many transition metal oxide and sulfide minerals that are not inert bystanders to the chemistry happening around them. This thesis takes from the environment the complicated matrix of hot pressurized water, organic material, and minerals, and breaks it down, systematically, in the laboratory to probe the effects hydrothermal conditions and minerals have on the reactivity of model organic compounds. I conducted experiments at 300°C and 100 MPa using water, organic reactants, and minerals. Methyl- and dimethyl-cyclohexane based reactants provided regio and sterio-chemical markers to indicate reaction mechanisms. Without minerals, I found that the cyclic alkanes undergo a series of reversible stepwise oxidation and hydration reactions forming alkenes-alcohols-ketones, and alkenes-dienes-aromatic rings. I also found the reactions to be reversible; the ketone was readily reduced to the alkane. When the reactions were carried out in the presence of minerals, there were sometimes dramatic effects including reaction rate enhancement and changes in product distributions. Minerals pushed the reaction in the direction of oxidation or reduction depending on the type of mineral used. The hydration reaction could be essentially “turned off” using pyrite (FeS2) and troilite (FeS), which eliminated formation of ketone products. In contrast, hematite (Fe2O3) and magnetite (Fe3O4) favored the hydration reaction and enhanced ketone production. Sphalerite (ZnS) was shown to act as a heterogeneous catalysis for alkane isomerization by activating the C-H bond and increasing reaction rates until thermodynamic equilibrium was reached. This suggests that the types of minerals present in hydrothermal environments will affect the functional group composition of organic material. Minerals and hot pressurized water may also have useful applications in organic chemistry as “green” reactants and catalysts.