There exist many facets of error and uncertainty in digital spatial information. As error or uncertainty will not likely ever be completely eliminated, a better understanding of its impacts is necessary. Spatial analytical approaches, in particular, must somehow address data quality issues. This can range from evaluating impacts of potential data uncertainty in planning processes that make use of methods to devising methods that explicitly account for error/uncertainty. To date, little has been done to structure methods accounting for error. This research focuses on developing methods to address geographic data uncertainty in spatial optimization. An integrated approach that characterizes uncertainty impacts by constructing and solving a new multi-objective model that explicitly incorporates facets of data uncertainty is developed. Empirical findings illustrate that the proposed approaches can be applied to evaluate the impacts of data uncertainty with statistical confidence, which moves beyond popular practices of simulating errors in data. Spatial uncertainty impacts are evaluated in two contexts: harvest scheduling and sex offender residency. Owing to the integration of spatial uncertainty, the detailed multi-objective models are more complex and computationally challenging to solve. As a result, a new multi-objective evolutionary algorithm is developed to address the computational challenges posed. The proposed algorithm incorporates problem-specific spatial knowledge to significantly enhance the capability of the evolutionary algorithm for solving the model.