This study focuses on three major Maghreb states (Algeria, Morocco and Tunisia) with distinct institutional, political and socioeconomic patterns. It essentially tackles the issue of technological development particularly investments, trade, human capital and patents in a socially and politically sensitive environment. The researcher assumes that government stability, law and order, GDP growth and ICT usage are related to technological innovation in the Maghreb. The stated hypotheses indicate that these political, institutional and socioeconomic factors have significant effect on technological innovation in the Maghreb. Based on a two equations' empirical model, our researcher attempts to test these effects and explore the interactions between the different dependent and independent variables through a set of hypotheses. Data analysis covers three countries from 1996 to 2010. The study identifies significant effects of key covariates on technological innovation in the Maghreb. Although not every predictor effect is consistent, the results indicate that they matter for technological innovation in the Maghreb. Empirical findings might constitute essential evidence for technology and innovation policies in this Middle East and North African region.