Adolescent substance use carries a considerable public health burden, and early initiation into use is especially problematic. Research has shown that sensation seeking traits increase risk for substance use experimentation, but less is known about individual and contextual factors that can potentially protect against this risk. This study utilized a longitudinal sub sample of youth (N=567) from a larger study of familial alcoholism to examine sensation seeking in early adolescence (ages 10-15) and its relations to later substance use experimentation. Hypotheses tested whether individual executive control, parenting consistency, neighborhood disadvantage, and neighborhood ethnic concentration moderated sensation seeking’s effects on substance use experimentation using multilevel zero-inflated Poisson modeling. Across models, higher levels of sensation seeking were predictive of a higher likelihood of having initiated substance use, but sensation seeking was not significantly related to the number of different substance use classes tried. Only neighborhood disadvantage emerged as a significant moderator of the path from sensation seeking to substance use initiation. The strength of sensation seeking effects on substance use initiation increased as neighborhood disadvantage decreased below average levels, with the most advantaged neighborhoods exhibiting the strongest link between sensation seeking and substance use. There was also a trend towards the most disadvantaged neighborhoods exhibiting increased sensation seeking effects on substance use initiation. These results highlight the importance of focusing on relatively more advantaged areas as potentially risky environments for the externalizing pathway to substance use.

Sexual risk taking is prevalent in adolescence, particularly among Latino teens, and can have serious consequences in the form of contraction of STIs, HIV, and increased risk of unintended pregnancy. Family contexts characterized by conflict and lack of support are antecedents of adolescent sexual risk taking, but evidence elucidating the mechanisms underlying this association is lacking. The current study sought to test two potential pathways to sexual risk taking within the framework of social developmental theory, among a sample of 189 Mexican origin adolescents and their caregivers interviewed in the 7th, 8th, and 12th grades. Structural equation modeling was utilized to examine pathways from 7th grade family risk to age of sexual initiation, number of lifetime sexual partners, and condom nonuse reported in the 12th grade. Deviant peer affiliations and academic engagement at 8th grade were tested as mediators of this relationship for boys and girls. Results confirm the importance of the family context, with family risk exerting direct effects on the number of lifetime sexual partners for both genders, and on age of sexual initiation for females only. Deviant peer affiliations serve as a mediator of family risk for males, but not females. When included in a model alongside deviant peers, academic engagement does not play the hypothesized mediating role between family risk and any of the sexual risk outcomes. Future research ought to consider additional mediators that better account for the relation between family risk and sexual risk taking among females.