Ambivalent Blood examines the unsettled status of religious language in the semiotic construction of HIV/AIDS in America. Since public discourse about HIV/AIDS began in 1981, a variety of religious grammars have been formulated, often at cross-purposes, to assign meaning to the epidemic. The disease's complex interaction with religion has been used to prophesize looming apocalypses, both religious and national, demand greater moral solicitude among the citizenry, forge political advantage within America's partisan political landscape, mobilize empathy and compassion for those stricken by the disease, and construct existential meaning for those who have already been consigned to physical and social death. Several studies fruitfully have explored specific registers of religious discourse and the AIDS epidemic, particularly in regard to processes of social stigmatization and combating its very effects. However, assumptions about the secular aims of scientific inquiry as well as the presumably secular trajectory of American national culture have dampened a more robust consideration of religion within the history of HIV/AIDS. In most synoptic histories of AIDS, religion is constructed as either a wincing footnote to the Religious Right or as an occasional and bland example of salubrious Christian charity posed against the backdrop of disease and death. Ambivalent Blood seeks to extend such analysis beyond a digestible footnote by disinterring the often polysemous and ambivalent interaction of HIV/AIDS and religious discourses within American culture. Though not a historiographic work, the current project illuminates the complicated ways in which religious and HIV/AIDS discourses coalesced around the very definition of America itself. Like the Cold War that preceded and the Global War on Terror that followed, the AIDS crisis precipitated significant and contested recourse to the religious imaginary in the effort to forge conceptions of Americanness and citizen belonging.