The purpose of this study is to explore the knowledge and attitudes about autism spectrum disorders among Hispanics in the Southwest. The study will also examine perceived barriers in obtaining resources and preferences in accessing health care. Participants (N = 169) were surveyed using the Autism Awareness Survey, which was developed specifically for this research. Significant differences were found between individuals with high acculturation and low acculturation in exposure to autism, knowledge about autism, perceived barriers to obtaining resources and health care, and attitudes towards people with autism. Additionally, the findings also suggest that although the surveyed population was knowledgeable about the symptoms associated with autism, less well known is the etiology and course of the disorder. The research underscores the serious need for both Spanish educational resources and Spanish-speaking health care providers to address the needs of Hispanics with regards to autism, especially with individuals with low levels of acculturation.