Medical images constitute a special class of images that are captured to allow diagnosis of disease, and their "correct" interpretation is vitally important. Because they are not "natural" images, radiologists must be trained to visually interpret them. This training process includes implicit perceptual learning that is gradually acquired over an extended period of exposure to medical images. This dissertation proposes novel computational methods for evaluating and facilitating perceptual training in radiologists. Part 1 of this dissertation proposes an eye-tracking-based metric for measuring the training progress of individual radiologists. Six metrics were identified as potentially useful: time to complete task, fixation count, fixation duration, consciously viewed regions, subconsciously viewed regions, and saccadic length. Part 2 of this dissertation proposes an eye-tracking-based entropy metric for tracking the rise and fall in the interest level of radiologists, as they scan chest radiographs. The results showed that entropy was significantly lower when radiologists were fixating on abnormal regions. Part 3 of this dissertation develops a method that allows extraction of Gabor-based feature vectors from corresponding anatomical regions of "normal" chest radiographs, despite anatomical variations across populations. These feature vectors are then used to develop and compare transductive and inductive computational methods for generating overlay maps that show atypical regions within test radiographs. The results show that the transductive methods produced much better maps than the inductive methods for 20 ground-truthed test radiographs. Part 4 of this dissertation uses an Extended Fuzzy C-Means (EFCM) based instance selection method to reduce the computational cost of transductive methods. The results showed that EFCM substantially reduced the computational cost without a substantial drop in performance. The dissertation then proposes a novel Variance Based Instance Selection (VBIS) method that also reduces the computational cost, but allows for incremental incorporation of new informative radiographs, as they are encountered. Part 5 of this dissertation develops and demonstrates a novel semi-transductive framework that combines the superior performance of transductive methods with the reduced computational cost of inductive methods. The results showed that the semi-transductive approach provided both an effective and efficient framework for detection of atypical regions in chest radiographs.

Social situational awareness, or the attentiveness to one's social surroundings, including the people, their interactions and their behaviors is a complex sensory-cognitive-motor task that requires one to be engaged thoroughly in understanding their social interactions. These interactions are formed out of the elements of human interpersonal communication including both verbal and non-verbal cues. While the verbal cues are instructive and delivered through speech, the non-verbal cues are mostly interpretive and requires the full attention of the participants to understand, comprehend and respond to them appropriately. Unfortunately certain situations are not conducive for a person to have complete access to their social surroundings, especially the non-verbal cues. For example, a person is who is blind or visually impaired may find that the non-verbal cues like smiling, head nod, eye contact, body gestures and facial expressions of their interaction partners are not accessible due to their sensory deprivation. The same could be said of people who are remotely engaged in a conversation and physically separated to have a visual access to one's body and facial mannerisms. This dissertation describes novel multimedia technologies to aid situations where it is necessary to mediate social situational information between interacting participants. As an example of the proposed system, an evidence-based model for understanding the accessibility problem faced by people who are blind or visually impaired is described in detail. From the derived model, a sleuth of sensing and delivery technologies that use state-of-the-art computer vision algorithms in combination with novel haptic interfaces are developed towards a) A Dyadic Interaction Assistant, capable of helping individuals who are blind to access important head and face based non-verbal communicative cues during one-on-one dyadic interactions, and b) A Group Interaction Assistant, capable of provide situational awareness about the interaction partners and their dynamics to a user who is blind, while also providing important social feedback about their own body mannerisms. The goal is to increase the effective social situational information that one has access to, with the conjuncture that a good awareness of one's social surroundings gives them the ability to understand and empathize with their interaction partners better. Extending the work from an important social interaction assistive technology, the need for enriched social situational awareness is everyday professional situations are also discussed, including, a) enriched remote interactions between physically separated interaction partners, and b) enriched communication between medical professionals during critical care procedures, towards enhanced patient safety. In the concluding remarks, this dissertation engages the readers into a science and technology policy discussion on the potential effect of a new technology like the social interaction assistant on the society. Discussing along the policy lines, social disability is highlighted as an important area that requires special attention from researchers and policy makers. Given that the proposed technology relies on wearable inconspicuous cameras, the discussion of privacy policies is extended to encompass newly evolving interpersonal interaction recorders, like the one presented in this dissertation.