Distributed inference has applications in fields as varied as source localization, evaluation of network quality, and remote monitoring of wildlife habitats. In this dissertation, distributed inference algorithms over multiple-access channels are considered. The performance of these algorithms and the effects of wireless communication channels on the performance are studied. In a first class of problems, distributed inference over fading Gaussian multiple-access channels with amplify-and-forward is considered. Sensors observe a phenomenon and transmit their observations using the amplify-and-forward scheme to a fusion center (FC). Distributed estimation is considered with a single antenna at the FC, where the performance is evaluated using the asymptotic variance of the estimator. The loss in performance due to varying assumptions on the limited amounts of channel information at the sensors is quantified. With multiple antennas at the FC, a distributed detection problem is also considered, where the error exponent is used to evaluate performance. It is shown that for zero-mean channels between the sensors and the FC when there is no channel information at the sensors, arbitrarily large gains in the error exponent can be obtained with sufficient increase in the number of antennas at the FC. In stark contrast, when there is channel information at the sensors, the gain in error exponent due to having multiple antennas at the FC is shown to be no more than a factor of 8/π for Rayleigh fading channels between the sensors and the FC, independent of the number of antennas at the FC, or correlation among noise samples across sensors. In a second class of problems, sensor observations are transmitted to the FC using constant-modulus phase modulation over Gaussian multiple-access-channels. The phase modulation scheme allows for constant transmit power and estimation of moments other than the mean with a single transmission from the sensors. Estimators are developed for the mean, variance and signal-to-noise ratio (SNR) of the sensor observations. The performance of these estimators is studied for different distributions of the observations. It is proved that the estimator of the mean is asymptotically efficient if and only if the distribution of the sensor observations is Gaussian.