Novel siloxane nanoprobes for molecular and cellular imagin
Description
Oxygen delivery is crucial for the development of healthy, functional tissue. Low tissue oxygenation, or hypoxia, is a characteristic that is common in many tumors. Hypoxia contributes to tumor malignancy and can reduce the success of chemotherapy and radiation treatment. There is a current need to noninvasively measure tumor oxygenation or pO2 in patients to determine a personalized treatment method. This project focuses on creating and characterizing nanoemulsions using a pO2 reporter molecule hexamethyldisiloxane (HMDSO) and its longer chain variants as well as assessing their cytotoxicity. We also explored creating multi-modal (MRI/Fluorescence) nanoemulsions.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2013-05
Agent
- Author (aut): Grucky, Marian Louise
- Thesis director: Kodibagkar, Vikram
- Committee member: Rege, Kaushal
- Committee member: Stabenfeldt, Sarah
- Contributor (ctb): Barrett, The Honors College
- Contributor (ctb): Harrington Bioengineering Program