The purpose of this study was to examine executive cognitive functioning (ECF) and drinking induced disinhibition as potential mechanisms through which a family history (FH) of alcohol problems contributes to off-spring alcohol-related problems. We also examined the hypotheses that indirect effects of family history would be moderated by age of drinking onset, hypothesizing that indirect effects of family history through ECF and drinking induced disinhibition would be stronger among those with an earlier age of drinking onset. The sample included 177 college aged heavy drinking participants (66.2% men; 33.8% women; 78.8% Caucasian; 10.1 % African American; 6.9% Hispanic; 4.2% Multi-racial; 4.8% other) participating in a randomized controlled trial of naltrexone (vs. placebo) plus brief motivational counseling for drinking reduction. Measures of family history, self-control, working memory, and drinking induced disinhibition collected prior to randomization to treatment condition (intake assessment), were used to explore the hypothesized mechanisms of FH effects. Although FH was not related to either working memory or self-control, self-control predicted both drinking induced disinhibition and alcohol-related problems, with a marginal indirect effect of self-control on problems through drinking induced disinhibition. Age of drinking onset did not moderate relations between FH and measures of ECF (working memory and self-control). The findings suggest that self-control is a major factor contributing to the development of alcohol-related problems. Thus self-control may be an important target of intervention regardless of age of drinking onset or family history status.