Objective: To explain the origins of the pediatric asthma cluster present in south and central phoenix, and propose potential solutions to combat this cluster. Methods: A comprehensive literature review of the different factors that contribute to asthma starting at a national level and working down to the Maricopa county level was conducted. Afterwards a literature review of past pediatric asthma intervention case studies was conducted. The results of both literature reviews were synthesized in regards to applicability in south and central phoenix. Results: A combined targeted intervention in health care delivery, patient/clinician education, and housing status/infrastructure could yield promising results in regards to combatting the pediatric asthma cluster in south and central phoenix.