Forensic anthropologists rely on the validated sex determination methods that utilize post-cranial elements in adult remains, but, recently, research has been conducted to determine adult remain sex using just the skull. Similar research for sub-adult remains is lacking the robustness and validation that adult determination methods possess. This study utilized 20 crania measurements taken from CT scans of child patients with known sexes at the Phoenix Children’s Hospital to investigate if a sex determination method could be produced. The measurements were assessed with a t-Test, Linear Discriminant Analysis, and Principle Component Analysis to determine if sexual dimorphism was detectable and if the predictive model had discriminant power when the sample size was categorized by age. The results revealed that a few measurements were dimorphic, but were not statistically significant to determine the sex of a sub-adult outside of the sample population. Future investigations will remove age group classification to observe if this model can predict age.