This dissertation addresses access management problems that occur in both emergency and outpatient clinics with the objective of allocating the available resources to improve performance measures by considering the trade-offs. Two main settings are considered for estimating patient willingness-to-wait (WtW) behavior for outpatient appointments with statistical analyses of data: allocation of the limited booking horizon to patients of different priorities by using time windows in an outpatient setting considering patient behavior, and allocation of hospital beds to admitted Emergency Department (ED) patients. For each chapter, a different approach based on the problem context is developed and the performance is analyzed by implementing analytical and simulation models. Real hospital data is used in the analyses to provide evidence that the methodologies introduced are beneficial in addressing real life problems, and real improvements can be achievable by using the policies that are suggested.

This dissertation starts with studying an outpatient clinic context to develop an effective resource allocation mechanism that can improve patient access to clinic appointments. I first start with identifying patient behavior in terms of willingness-to-wait to an outpatient appointment. Two statistical models are developed to estimate patient WtW distribution by using data on booked appointments and appointment requests. Several analyses are conducted on simulated data to observe effectiveness and accuracy of the estimations.

Then, this dissertation introduces a time windows based policy that utilizes patient behavior to improve access by using appointment delay as a lever. The policy improves patient access by allocating the available capacity to the patients from different priorities by dividing the booking horizon into time intervals that can be used by each priority group which strategically delay lower priority patients.

Finally, the patient routing between ED and inpatient units to improve the patient access to hospital beds is studied. The strategy that captures the trade-off between patient safety and quality of care is characterized as a threshold type. Through the simulation experiments developed by real data collected from a hospital, the achievable improvement of implementing such a strategy that considers the safety-quality of care trade-off is illustrated.

Breeding seeds to include desirable traits (increased yield, drought/temperature resistance, etc.) is a growing and important method of establishing food security. However, besides breeder intuition, few decision-making tools exist that can provide the breeders with credible evidence to make decisions on which seeds to progress to further stages of development. This thesis attempts to create a chance-constrained knapsack optimization model, which the breeder can use to make better decisions about seed progression and help reduce the levels of risk in their selections. The model’s objective is to select seed varieties out of a larger pool of varieties and maximize the average yield of the “knapsack” based on meeting some risk criteria. Two models are created for different cases. First is the risk reduction model which seeks to reduce the risk of getting a bad yield but still maximize the total yield. The second model considers the possibility of adverse environmental effects and seeks to mitigate the negative effects it could have on the total yield. In practice, breeders can use these models to better quantify uncertainty in selecting seed varieties

One of the critical issues in the U.S. healthcare sector is attributed to medications management. Mismanagement of medications can not only bring more unfavorable medical outcomes for patients, but also imposes avoidable medical expenditures, which can be partially accounted for the enormous $750 billion that the American healthcare system wastes annually. The lack of efficiency in medical outcomes can be due to several reasons. One of them is the problem of drug intensification: a problem associated with more aggressive management of medications and its negative consequences for patients.

To address this and many other challenges in regard to medications mismanagement, I take advantage of data-driven methodologies where a decision-making framework for identifying optimal medications management strategies will be established based on real-world data. This data-driven approach has the advantage of supporting decision-making processes by data analytics, and hence, the decision made can be validated by verifiable data. Thus, compared to merely theoretical methods, my methodology will be more applicable to patients as the ultimate beneficiaries of the healthcare system.

Based on this premise, in this dissertation I attempt to analyze and advance three streams of research that are influenced by issues involving the management of medications/treatments for different medical contexts. In particular, I will discuss (1) management of medications/treatment modalities for new-onset of diabetes after solid organ transplantations and (2) epidemic of opioid prescription and abuse.

The findings of this project show that through the use of principal component analysis and K-Means clustering, NBA players can be algorithmically classified in distinct clusters, representing a player archetype. Individual player data for the 2018-2019 regular season was collected for 150 players, and this included regular per game statistics, such as rebounds, assists, field goals, etc., and advanced statistics, such as usage percentage, win shares, and value over replacement players. The analysis was achieved using the statistical programming language R on the integrated development environment RStudio. The principal component analysis was computed first in order to produce a set of five principal components, which explain roughly 82.20% of the total variance within the player data. These five principal components were then used as the parameters the players were clustered against in the K-Means clustering algorithm implemented in R. It was determined that eight clusters would best represent the groupings of the players, and eight clusters were created with a unique set of players belonging to each one. Each cluster was analyzed based on the players making up the cluster and a player archetype was established to define each of the clusters. The reasoning behind the player archetypes given to each cluster was explained, providing details as to why the players were clustered together and the main data features that influenced the clustering results. Besides two of the clusters, the archetypes were proven to be independent of the player's position. The clustering results can be expanded on in the future to include a larger sample size of players, and it can be used to make inferences regarding NBA roster construction. The clustering can highlight key weaknesses in rosters and show which combinations of player archetypes lead to team success.

The premise of this thesis developed from my personal interests and undergraduate educational experiences in both industrial engineering and design studies, particularly those related to product design. My education has stressed the differences in the ways that engineers and designers approach problem solving and creating solutions, but I am most interested in marrying the two mindsets of designers and engineers to better solve problems creatively and efficiently.
This thesis focuses on the recent appearance of generative design technology into the world of industrial design and engineering as it relates to product development. An introduction to generative design discusses the uses and benefits of this tool for both designers and engineers and also addresses the challenges of this technology. The relevance of generative design to the world of product development is discussed as well as the implications of how this technology will change the roles of designers and engineers, and especially their traditional design processes. The remainder of this paper is divided into two elements. The first serves as documentation of my own exploration of using generative design software to solve a product design challenge and my reflections on the benefits and challenges of using this tool. The second element addresses the need for employing quantitiative methodologies within the generative design process to aid designers in selecting the most advantageous design option when presented with generative outcomes. Both sections aim to provide more context to this new design process and seek to answer questions about some of the ambiguous processes of generative design.

Revenue management (RM) attempts to understand and shape consumer behavior to maximize revenue from a perishable resource. Various algorithms can be used to control bid-prices, and subsequently, perform differently with respect to the total network revenue that they generate. There is currently a need for some method to compare RM engines; a simulation can fulfill this need.

The first module of this thesis will create a statistically accurate representation of customers arriving at ticket purchasing channels. Each customer's attributes are: arrival time, origin and destination, number of destined tickets, and willingness to pay. Each attribute can be generated using a specific distribution.

The created customers will then be used to simulate the purchase of tickets and overall revenue for a flight network. With a valid simulation, airlines will be able to compare the performance of different RM engines under various circumstances.

Project portfolio selection (PPS) is a significant problem faced by most organizations. How to best select the many innovative ideas that a company has developed to deploy in a proper and sustained manner with a balanced allocation of its resources over multiple time periods is one of vital importance to a company's goals. This dissertation details the steps involved in deploying a more intuitive portfolio selection framework that facilitates bringing analysts and management to a consensus on ongoing company efforts and buy into final decisions. A binary integer programming selection model that constructs an efficient frontier allows the evaluation of portfolios on many different criteria and allows decision makers (DM) to bring their experience and insight to the table when making a decision is discussed. A binary fractional integer program provides additional choices by optimizing portfolios on cost-benefit ratios over multiple time periods is also presented. By combining this framework with an `elimination by aspects' model of decision making, DMs evaluate portfolios on various objectives and ensure the selection of a portfolio most in line with their goals. By presenting a modeling framework to easily model a large number of project inter-dependencies and an evolutionary algorithm that is intelligently guided in the search for attractive portfolios by a beam search heuristic, practitioners are given a ready recipe to solve big problem instances to generate attractive project portfolios for their organizations. Finally, this dissertation attempts to address the problem of risk and uncertainty in project portfolio selection. After exploring the selection of portfolios based on trade-offs between a primary benefit and a primary cost, the third important dimension of uncertainty of outcome and the risk a decision maker is willing to take on in their quest to select the best portfolio for their organization is examined.

This paper explores the ability to predict yields of soybeans based on genetics and environmental factors. Based on the biology of soybeans, it has been shown that yields are best when soybeans grow within a certain temperature range. The event a soybean is exposed to temperature outside their accepted range is labeled as an instance of stress. Currently, there are few models that use genetic information to predict how crops may respond to stress. Using data provided by an agricultural business, a model was developed that can categorically label soybean varieties by their yield response to stress using genetic data. The model clusters varieties based on their yield production in response to stress. The clustering criteria is based on variance distribution and correlation. A logistic regression is then fitted to identify significant gene markers in varieties with minimal yield variance. Such characteristics provide a probabilistic outlook of how certain varieties will perform when planted in different regions. Given changing global climate conditions, this model demonstrates the potential of using data to efficiently develop and grow crops adjusted to climate changes.

Most staff planning for airline industries are done using point estimates; these do not account for the probabilistic nature of employees not showing up to work, and the airline company risks being under or overstaffed at different times, which increases costs and deteriorates customer service. This model proposes utilizing a stochastic method for American Airlines to schedule their ground crew staff. We developed a stochastic model for scheduling that incorporates the risks of absent employees and as well as reliability so that stakeholders can determine the level of reliability they want to maintain in their system based on the costs. We also incorporated a preferences component to the model in order to increase staff satisfaction in the schedules they get assigned based on their predetermined preferences. Since this is a general staffing model, this can be utilized for an airline crew or virtually any other workforce so long as certain parameters about the population can be determined.

The efficient refurbishment of rotable parts on an aircraft proves to be a main concern for airline carriers today. Airlines must be able to seamlessly rotate parts into and out of the system for maintenance in accordance with FAA requirements while leaving daily operations uninterrupted. In this paper, we develop an airline maintenance scheduling model that constructs an optimal schedule for part maintenance over a given time horizon using deterministic forecasting techniques. The model generates a schedule that minimizes the total cost of a maintenance schedule solution while maximizing the utility of all parts in the system. The model is then tested against actual network data of three part types crucial to airline operations and used to investigate the current data collection processes of US Airways maintenance lead time metrics. Manual sensitivity analysis is performed to generate the marginal value of each parameter and potential model extensions are highlighted as a result of these conclusions.