Alcohol consumption in first-year college students is both prevalent and problematic. Although several interventions have been shown to decrease alcohol consumption in college students, effect sizes tend to be small. Previous programs have focused on reducing risk factors; however, some research has shown potential in bolstering promotive and protective factors. The main objective of the current study was to further our understanding of the use of promotive and protective factors in alcohol prevention and intervention for first-year college students. A sample of 290 college psychology majors were assigned to either a treatment group or the standard curriculum of a first-semester course on achieving academic success. The intervention included activities aimed to increase academic engagement and community engagement, promote healthy minds and bodies, and promote positive social lives, including engagement in alcohol-free social activities. Students completed baseline measures at the beginning of the fall semester of their first year in college and a follow-up near the end of the semester. Analyses examined proximal targets (use of university resources, perceptions of peer alcohol use, academic engagement, school connectedness) and behavioral targets (personal alcohol use and GPA) of the intervention. Analyses demonstrated changes in proximal targets, but no significant effects of the intervention on behavioral targets. Students in the treatment condition utilized more school resources, had lower perceptions of peer alcohol use, and were marginally higher in school connectedness than those in the control condition. This suggests that the use of promotive and protective factors in alcohol prevention and intervention may contribute to attitudes and behaviors that are associated with better academic performance and less engagement in risk behavior. However, no significant changes were found for personal alcohol use or GPA. Future studies involving longer follow-ups and adding a skills-based component are needed to fully evaluate the potential of this approach.