Transcriptomic Characterization of In Vitro Retinal Microvasculature Structures in Diabetes
Description
Diabetic retinopathy is a disorder that affects many individuals with type 1 and type 2 diabetes mellitus. Due to increased blood glucose levels, microvessels in the retina become leaky, leading to vision loss. Through a cell culture model, this project aims to set a protocol in establishing a microvascular structure as well as investigate genetic changes that occur with the onset of diabetes. This project showcases images of microvascular-like structures which show progress into full microvascular formation as well as single cell sequencing data showing an endothelial cluster in microvascular-like structures.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2022-05
Agent
- Author (aut): Gupta, Raj
- Thesis director: Rangasamy, Sampathkumar
- Committee member: Legendre, Christophe
- Contributor (ctb): Barrett, The Honors College