Creation and Validation of an Automated Head Twitch Analysis Instrument to Study a Mouse Model of Psychosis
Description
Serotonin 2A receptor (5-HT2AR) levels are decreased in the brains of schizophrenia patients. This phenomenon is modeled in mice that lack the transcription factor Egr3. The head-twitch response (HTR) is a behavioral assay used to assess the physiological function of 5-HT2ARs. However, current quantification methods are time consuming and prone to inter-rater variability. Here, we demonstrate the validity and reliability of an automated head-twitch system to quantify HTRs of Egr3-/- mice.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2020-05
Agent
- Author (aut): Ozols, Annika Biruta
- Thesis director: Lisenbee, Cayle S.
- Committee member: Gallitano, Amelia L.
- Contributor (ctb): College of Health Solutions
- Contributor (ctb): Barrett, The Honors College