Chemiluminescent reagents, such as BlueStar® forensic reagent, are used during crime scene investigations to detect latent bloodstains as they react with the iron in blood to produce bright chemiluminescence. There are several substances that cause false positives with BlueStar® reagent, including plant peroxidases and certain metal compounds. These false positive substances are commonly seen in cosmetic products. The widespread availability and popularity of cosmetics makes it possible that false positive substances may be encountered at crime scenes and could potentially interfere with investigations. The cosmetic products chosen for this study included two of the following types of products at different price points: foundation, primer, moisturizer, cleanser, and setting powder. The ten cosmetic products were tested with BlueStar® forensic reagent in two rounds of testing on multiple surface types to mimic different ways investigators may encounter the products at crime scenes. The results of the tests were overall negative as the products did not produce any chemiluminescence, indicating that the products do not cause false positives with the BlueStar® forensic reagent and are not concern for investigators. As a majority of the products contain ingredients known to cause false positives with BlueStar®, the completely negative results raised several questions. More exploration of the interaction between cosmetic products and BlueStar® reagents needs to occur in order to clarify and confirm if cosmetics pose a risk to crime scene investigators.