Xerostomia and the Microbiome of the Mouth

136192-Thumbnail Image.png
Description
Is it possible to treat the mouth as a natural environment, and determine new methods to keep the microbiome in check? The need for biodiversity in health may suggest that every species carries out a specific function that is required

Is it possible to treat the mouth as a natural environment, and determine new methods to keep the microbiome in check? The need for biodiversity in health may suggest that every species carries out a specific function that is required to maintain equilibrium and homeostasis within the oral cavity. Furthermore, the relationship between the microbiome and its host is mutually beneficial because the host is providing microbes with an environment in which they can flourish and, in turn, keep their host healthy. Reviewing examples of larger scale environmental shifts could provide a window by which scientists can make hypotheses. Certain medications and healthcare treatments have been proven to cause xerostomia. This disorder is characterized by a dry mouth, and known to be associated with a change in the composition, and reduction, of saliva. Two case studies performed by Bardow et al, and Leal et al, tested and studied the relationships of certain medications and confirmed their side effects on the salivary glands [2,3]. Their results confirmed a relationship between specific medicines, and the correlating complaints of xerostomia. In addition, Vissink et al conducted case studies that helped to further identify how radiotherapy causes hyposalivation of the salivary glands [4]. Specifically patients that have been diagnosed with oral cancer, and are treated by radiotherapy, have been diagnosed with xerostomia. As stated prior, studies have shown that patients having an ecologically balanced and diverse microbiome tend to have healthier mouths. The oral cavity is like any biome, consisting of commensalism within itself and mutualism with its host. Due to the decreased salivary output, caused by xerostomia, increased parasitic bacteria build up within the oral cavity thus causing dental disease. Every human body contains a personalized microbiome that is essential to maintaining health but capable of eliciting disease. The Human Oral Microbiomics Database (HOMD) is a set of reference 16S rRNA gene sequences. These are then used to define individual human oral taxa. By conducting metagenomic experiments at the molecular and cellular level, scientists can identify and label micro species that inhabit the mouth during parasitic outbreaks or a shifting of the microbiome. Because the HOMD is incomplete, so is our ability to cure, or prevent, oral disease. The purpose of the thesis is to research what is known about xerostomia and its effects on the complex microbiome of the oral cavity. It is important that researchers determine whether this particular perspective is worth considering. In addition, the goal is to create novel experiments for treatment and prevention of dental diseases.
Date Created
2015-05
Agent

How to Survive College

Description
Attending college brings on new experiences and challenges. In order to survive college, a student must figure out what resources are available to them and what will help them succeed. The purpose of this study is to learn about what

Attending college brings on new experiences and challenges. In order to survive college, a student must figure out what resources are available to them and what will help them succeed. The purpose of this study is to learn about what students struggle with the most. Students were also asked about what advice they have for future students and what they would change about their own experience. Participants of the study consisted of ASU students 18 or older. Information was collected through interviews, an online survey, and a paper survey. Many students feel that high school has not prepared them for college. Some students continue to struggle with time management. With students coming from many different backgrounds, it is up to the college to provide resources to help students to succeed. However, it is up to the student to make the effort to find, ask, and use these resources. The student ultimately decides to use the resources and tools provided to them in order to survive college.
Date Created
2016-05
Agent

Iron City Magazine: Creative Expressions By and For the Incarcerated

135784-Thumbnail Image.png
Description
Iron City Magazine is an online and print journal devoted entirely to writing and art from the prison world. It is our hope that through this creative platform, incarcerated artists and writers find value in their stories, fuel for personal

Iron City Magazine is an online and print journal devoted entirely to writing and art from the prison world. It is our hope that through this creative platform, incarcerated artists and writers find value in their stories, fuel for personal growth, and pride in their accomplishments. Inmates are, first and foremost, people. They own stories worthy of telling and sharing. Iron City Magazine aims to highlight these stories in a way more permanent than a private journal. In addition, we serve to remind the general public that inmates can make meaningful contributions to their communities. So often, this potential is forgotten or overshadowed by their crimes. By validating inmates' humanity through writing and art, we encourage a culture of understanding and transformation.
Date Created
2016-05
Agent