Therapeutic Target Exploration in Triple Negative Breast Cancer
Description
This investigation investigates the impact of ARAF knockdown on the invasion capabilities of breast epithelial cells carrying the TP53 R273C mutation, a prevalent genetic alteration in triple-negative breast cancer (TNBC). Through the use of invasion assays, the study uncovers an unexpected increase in invasion following ARAF knockdown in mutant cell lines. Further analysis hints at the presence of a novel truncated ARAF protein, challenging traditional notions of ARAF's role in cancer. These findings offer insights into potential therapeutic targets for TNBC and underscore the significance of exploring the functional implications of genetic mutations in cancer progression.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2024-05
Agent
- Author (aut): Leaver, Jory
- Thesis director: Park, Jin
- Committee member: Grief, Dustin
- Contributor (ctb): Barrett, The Honors College
- Contributor (ctb): School of Life Sciences