Learning Continuous 2D Diffusion Maps from Particle Trajectories without Data Binning
Description
Diffusion coefficients often vary across regions, such as cellular membranes, and quantifying their variation can provide valuable insight into local membrane properties such as composition and stiffness. Toward quantifying diffusion coefficient spatial maps and uncertainties from particle tracks, we use a Bayesian method and place Gaussian Process (GP) Priors on the maps. For the sake of computational efficiency, we leverage inducing point methods on GPs arising from the mathematical structure of the data giving rise to non-conjugate likelihood-prior pairs. We analyze both synthetic data, where ground truth is known, as well as data drawn from live-cell single-molecule imaging of membrane proteins. The resulting tool provides an unsupervised method to rigorously map diffusion coefficients continuously across membranes without data binning.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2024-05
Agent
- Author (aut): Kumar, Vishesh
- Thesis director: Presse, Steve
- Committee member: Bryan IV, J. Shep
- Contributor (ctb): Barrett, The Honors College
- Contributor (ctb): School of Mathematical and Statistical Sciences
- Contributor (ctb): Department of Physics