This Honors thesis was written in partial fulfillment of the requirements for a Bachelor of Science in Human Systems Engineering with Honors. The project consists of a literature review that explores the uses and applications of Machine Learning and Artificial Intelligence techniques in the field of commercial aviation. After a brief introduction and explanation of the most commonly used algorithms in the field of aviation, it explores the applications of Machine Learning techniques for risk reduction, and for the betterment of in-flight operations, and pilot selection, training, and assessment.