Investigation of Synthesis of Beta-Cyclodextrin into an Anti-Viral Platform
Description
Cyclodextrins are known for their pharmaceutical applications in a range of pathologies. Beta(ꞵ)-cyclodextrins have been suggested to be effective scaffolds that can ligate to peptides when chemically modified, which has the potential to be cost-effective in comparison to other available treatments for antiviral therapeutics. It is hypothesized that a ꞵ-cyclodextrin platform can be modified through a few-step reaction process to develop a ꞵ-cyclodextrin-DBCO-GFP nanobody. The findings of this few-step reaction support the general approach of conjugating the ꞵ-cyclodextrin derivative to GPF nanobody for developing a cyclodextrin antiviral scaffold.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2023-05
Agent
- Author (aut): Taniguchi, Tohma
- Thesis director: Hariadi, Rizal
- Committee member: Stephanopoulos, Nicholas
- Committee member: Sasmal, Ranjan
- Contributor (ctb): Barrett, The Honors College
- Contributor (ctb): School of Molecular Sciences